Depth of focus of the eye is influenced by a variety of factors, such as pupil size and ocular aberrations. This project aims to further understand the way in which depth of focus changes with the changes that occur in the crystalline lens during accommodation and with age. These changes will be then mathematically modelled.  The basis of this project will be the information gathered about Age-related changes in the optics of the human eye with accommodation and anatomical and structural changes of the crystalline lens with accommodation and age. The theoretical background provided by the projects described above and the experimental data gathered in this one will help to develop accurate mathematical depth-of-focus models and possible ways to alter depth of focus.

Supervisors: I. Murray & N. López-Gil Coll.: D. Madrid-Costa & R. Iskander

Early Stage Researcher 5:  Juan F. Zapata Díaz

Host Institution: University of Manchester (United Kingdom)


Click here to watch a video presentation of the project presented by Juan F. Zapata Díaz

To better understand the optical properties of the human crystalline lens, we must be able to model it accurately. Its two critical properties are shape and internal distribution of the gradient refractive index. In the past, different mathematical models to describe the lens shape have been proposed. However, none of the models considered the dynamic behaviour of the lens. The project aims to develop a comprehensive model of the anterior eye segment (cornea and lens) that includes the effect of temporal changes in optical microfluctuations, accommodation and age. Information from all other subprojects will be combined into this development

Supervisors: R. Iskander & H Radhakrishnan Coll.: R. Montés-Micó & N. López-Gil

Early Stage Researcher 6:  Alejandra Consejo-Vaquero

Host Institution: Institute of Biomedical Engineering and Instrumentation, Politechnika Wroclawska (Poland)


Click here to watch a video presentation of the project presented by Alejandra Consejo-Vaquero

Standard clinical methods will be used (Badal optometers, minus lenses and push-up) to obtain the subjective refraction (SRx), the amplitude of accommodation (AA) and the depth of focus (DoF), in conjunction with experimental objective systems based on wavefront refraction. Objective data will be processed using different image-quality metrics and the results will be compared with subjective data, in order to find objective predictors of the SRx, AA and DoF under different situations. Experimental results will be of great interest for the eye-modelling tasks and to explain changes undergone by the aging eye with accommodation.

Supervisors: N. López-Gil & R. Iskander. Coll.: H. Radhakrishnan & N. Chateau

Early Stage Researcher 7:  Matt Jaskulski

Host Institution: University of Murcia (Spain)


Click here to watch a video presentation of the project presented by Matt Jaskulski

By means of adaptive optics, using a visual simulator, we will assess in vivo and in real subjects the visual function provided by the various optical designs measured previously. This will give us comparative data on the performance of the different optical solutions to correct presbyopia, without the need of surgery. Results of this project will be linked to the mathematical models obtained and to the new optical designs developed. This project will help to develop new optical designs to improve presbyopic corrections using both contact and intraocular lenses.

Supervisors: D. Madrid-Costa & H. Radhakrishnan, Coll.: N. López-Gil & C. Spera

Early Stage Researcher 8:  Eleni Papadatou

Host Institution: University of Valencia (Spain)


Click here to watch a video presentation of the project presented by Eleni Papadatou.

In cataract surgery, once the opacified crystalline lens has been removed and replaced with an artificial intraocular lens (IOL), straylight values are significantly lower than preoperative ones. However, they are still higher than expected (i.e., higher than those found in age-matched patients whose eyes have a clear crystalline lens). The reason for this is still unknown. The aim of this study is to measure IOLs' optical quality both in vivo and in vitro, and to determine sources of increased intraocular scatter in pseudophakic eyes. These results will be used in to simulate visual quality of different optical designs and to model the optical design of lenses to reduce light scattering.

Supervisors: T. van den Berg & N. López-Gil, Coll.: T. Ferrer-Blasco & N. Reus

Early Stage Researcher 9:  Grzegorz Labuz

Host Institution: The Rotterdam Ophthalmic Institute (The Netherlands)


Click here to watch a video presentation of the project presented by Grzegorz Labuz