Author: Danilo Andrade de Jesús, Wroclaw University of Technology
Intraocular pressure (IOP) is routinely assessed by noncontact applanation tonometry and its normal level ranges from about 10 to 21 mmHg. The accuracy of applanation tonometry is influenced by corneal stiffness that varies with a number of parameters, such as thickness, curvature and age.
Cornea is found to increase its stiffness as the characteristics of viscoelastic behaviour decrease with age. Such changes in corneal micro-structure contribute to a variation of corneal biomechanical variables which may be independent of central corneal thickness (CCT) or IOP. However, the assessment of the micro-structure effect in corneal tissue stiffness was limited to few studies due to the lack of means to measure it in vivo. Recent studies have suggested that the measured IOP should be corrected by the CCT and an age-dependent correction factor, pointing that an increase of corneal thickness in a young person has a lower influence on the measured IOP than the same increase of thickness in an older subject. Despite the assumption made by these studies, ageing is not necessarily a linear process and may differently affect each subject. Parameters such as medical history (i.e., diabetes or topical drugs), ocular anatomy, sun exposure, alimentation or ethnicity may all play a role in that process. Moreover, the actual correction does not apply to other factors such corneal swelling, wound healing, and diseases such as keratoconus that all have possible effect on corneal micro-structure and hence, subsequently, on the IOP measurements. Therefore, new techniques are needed to measure in vivo the contribution of the corneal micro-structure on the IOP measurement.
In a manuscript published this month in PloS One, we show, for the first time, that corneal micro-structure plays an important role in IOP measurements obtained from noncontact tonometry. The proposed technique of statistically modelling OCT speckle introduces a new approach to provide complementary information to better understand the influence of alterations of the collagen framework on ocular tonometry.
Article Source: Influence of eye biometrics and corneal micro-structure on noncontact tonometry
Jesus DA, Majewska M, Krzyżanowska-Berkowska P, Iskander DR (2017) Influence of eye biometrics and corneal micro-structure on noncontact tonometry. PLOS ONE 12(5): e0177180. https://doi.org/10.1371/journal.pone.0177180
Author: Alejandra Consejo, Wroclaw University of Science and Technology
Alejandra Consejo, research fellow at Wroclaw University of Science and Technology, submitted in January this year her doctoral thesis entitled ‘The anterior eye surface: age, accommodation and contact lens wear’. From February she has been working in the Department of Ophthalmology in Antwerp University Hospital, UZA (Antwerp, Belgium), in the Physiological Optics research group with Professor Jos Rozema, Professor Marie-José Tassignon and Professor Carina Koppen. She is primarily involved in a research project that aims to develop an accurate tool for the early detection of keratoconus using Machine Learning techniques. In addition, Alejandra is still collaborating with her ITN Marie Curie host institution. She is the principal investigator of the project ‘Investigating changes in corneo-scleral topography as a consequence of contact lens wear’. This project, financed by the polish National Center of Science, is the continuation of one of her mayor PhD outcomes, this is how contact lens wear affects the ocular surface. It is a multidisciplinary international project in collaboration with Professor D. Robert Iskander from Wroclaw University of Science and Technology (Poland) and Professor James Wolffsohn from Aston University (United Kingdom).
Author: Irene Sisó-Fuertes, University of Manchester
Irene Sisó-Fuertes, research fellow at the University of Manchester, has been investigating about the age-related changes in the optics of the human eye with accommodation. During the three years in which she has been active part of the AGEYE project, she has received invaluable training that has improved her research skills as well as increased her network. All the skills acquired along with the experience gained have boosted her curriculum helping her to find a new position at the Manchester Royal Eye Hospital.
Irene will be part of the Manchester Vision Regeneration (MVR) Lab team, which is a research team that focuses on developing research and treatment strategies in Medical Retinal and Vitreoretinal conditions using the most advanced diagnostic and treatment devices.
Author: Cari Pérez Vives, PhD, Medical Affairs, Alcon Management (Switzerland)
Cari Pérez Vives, Experienced researcher of the Ageye Marie Curie ITN, during the last two years has performed her project in Alcon laboratories belonging to the Medical Affairs team. Cari Perez has supported the team on Surgical and Vision Care projects including scientific input into manuscripts, research proposals, promotional material and presentations. She has been collaborating very closely to other departments, such as Marketing, Market Access and the Clinical team and has been involved in some new product launches.
After her Post-Doctoral Fellowship, Cari Perez has been hired by Alcon EMEA as Medical Affairs Cataract Advisor being a permanent member of the team. She will be on charge of providing scientific and medical expertise for the brand plan, reviewing and advising study protocols, coordinating and monitoring scientific and medical information quality, providing guidance and content for medical training on assigned products and projects, congresses preparation and competitive intelligence.
The Ageye project offered her the opportunity to discover the industry, increase her network, grow professionally in another field out of the purely research and finally she got a permanent position in Alcon, a multinational company, which is the leader in eye care.
Author: Grzegorz Labuz, Rotterdam Ophthalmic Institute
Disability glare has often been associated with multifocal contact lenses. However, how different optical designs affect ocular straylight has never been studied. A new paper in Optometry & Vision Science authored by members of the Ageye Marie Curie ITN gives new insight into this issue.
Łabuz G, López-Gil N, van den Berg TJ, Vargas-Martín F. Ocular Straylight with Different Multifocal Contact Lenses. Optom Vis Sci. 2016 Dec 22. doi: 10.1097/OPX.0000000000001043